Application of membrane-active peptides for nonviral gene delivery
Identifieur interne : 002623 ( Main/Exploration ); précédent : 002622; suivant : 002624Application of membrane-active peptides for nonviral gene delivery
Auteurs : Ernst Wagner [Autriche]Source :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 1999.
English descriptors
- Teeft :
- Acad, Acta, Adenovirus, Adenovirus particles, Amphipathic, Amphipathic peptides, Biochem, Biochemistry, Biochim, Biol, Biophys, Birnstiel, Cationic, Cationic lipids, Cationic liposomes, Chem, Diphtheria toxin, Drug delivery reviews, Endocytosis, Endosomal, Endosomal membrane, Endosomal release, Endosome, Gene, Gene delivery, Gene expression, Gene therapy, Gene transfer, Intracellular, Ligand, Lipid, Lipofection, Liposome, Mammalian cells, Mechtler, Membrane, Membrane barriers, Membrane fusion, Natl, Nonviral, Nucleic, Nucleic acids, Other polycations, Pathway, Peptide, Peptide sequence, Polyfection, Polylysine, Polymer, Proc, Receptor, Synthetic peptides, Szoka, Toxin, Transfection, Transfection activity, Vesicle, Viral, Vivo gene transfer.
Abstract
Abstract: A variety of membrane-modifying agents including pH-specific fusogenic or lytic peptides, bacterial proteins, lipids, glycerol, or inactivated virus particles have been evaluated for the enhancement of DNA–polycation complex-based gene transfer. The enhancement depends on the characteristics of both the cationic carrier for DNA and the membrane-modifying agent. Peptides derived from viral sequences such as the N-terminus of influenza virus haemagglutinin HA-2, the N-terminus of rhinovirus HRV2 VP-1 protein, and other synthetic or natural sequences such as the amphipathic peptides GALA, KALA, EGLA, JTS1, or gramicidin S have been tested. Ligand–polylysine-mediated gene transfer can be improved up to more than 1000-fold by membrane-active compounds. Other polycations like dendrimers or polyethylenimines as well as several cationic lipids provide a high transfection efficiency per se. Systems based on these polymers or lipids are only slightly enhanced by endosomolytic peptides or adenoviruses. Electroneutral cationic lipid–DNA complexes however can be strongly improved by the addition of membrane-active peptides.
Url:
DOI: 10.1016/S0169-409X(99)00033-2
Affiliations:
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The enhancement depends on the characteristics of both the cationic carrier for DNA and the membrane-modifying agent. Peptides derived from viral sequences such as the N-terminus of influenza virus haemagglutinin HA-2, the N-terminus of rhinovirus HRV2 VP-1 protein, and other synthetic or natural sequences such as the amphipathic peptides GALA, KALA, EGLA, JTS1, or gramicidin S have been tested. Ligand–polylysine-mediated gene transfer can be improved up to more than 1000-fold by membrane-active compounds. Other polycations like dendrimers or polyethylenimines as well as several cationic lipids provide a high transfection efficiency per se. Systems based on these polymers or lipids are only slightly enhanced by endosomolytic peptides or adenoviruses. Electroneutral cationic lipid–DNA complexes however can be strongly improved by the addition of membrane-active peptides.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Wagner, Ernst" sort="Wagner, Ernst" uniqKey="Wagner E" first="Ernst" last="Wagner">Ernst Wagner</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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